In females beneath the age twenty five years, high educational level (Or dos.6, 95% CI 1.1–6.1), and more than one regular (Or dos.1, 95% CI step 1.1–cuatro.1) or informal (Or 1.7, 95% CI 1.0–dos.9) sexual spouse forecast illness exposure (Desk 4). You will find together with an advice out of an increased chance which have latest accessibility dental contraceptives (Otherwise 2.0, 95% CI 0.6–step one.5 – Desk 4). The addition of female probably a teen medical center (ages thirteen–17 years) didn’t build a bias regarding the research results, as the zero statistically high variations have been located after they was indeed excluded from the studies. The fresh organization with quantity of partners continuous that have a slightly lower potential ratio (Otherwise step one.eight, 95% CI 0.7–4.2). While doing so, the brand new association having education is more powerful (Otherwise seven.cuatro, 95% CI step one.9–31.0 to have high-level regarding training).
nine, 95% CI step one.step 3–step three.0 – Desk cuatro). Former entry to oral contraceptives improved the new illness risk slightly (Or 1.six, 95% CI 1.0–2.5) and you can parity some reduces the risk (Otherwise 0.5, 95% CI 0.2–1.2). Zero obvious development out-of association is actually noticed certainly one of feminine old 35 or even more decades. The research had diminished feminine of your own ages of 55 years or even more so that after that subgroup analysis with meaningful statistical electricity.
Early age and you may advanced away from hit knowledge was in fact most useful predictors regarding numerous infections than just out-of solitary ones (Dining table 5). To have several bacterial infections, there is certainly a pattern to possess a protective aftereffect of parity (for three or maybe more pupils as compared to nulliparous, Otherwise 0.5, 95% CI 0.2–step 1.3) and employ out-of condoms (Otherwise 0.5, 95% CI 0.3–0.9) (Desk 5). Most of the time, not, checked-out features shared equivalent associations that have solitary and numerous problems.
Discussion
To date, couples studies analyzed years-certain HPV incidence activities and you can determinants of HPV infection certainly female that hvorfor er thai piger sГҐ smukke have typical cytology when you look at the places with high incidence out of cervical cancers. We report right here the first studies of this type carried out in Colombia. An overall total HPV DNA frequency out of fourteen.9% try discover, which is similar to you to stated in other highest-risk communities in Mexico (14.5%) (Lazcano ainsi que al, 2001) and you can Costa Rica (16%) (Herrero mais aussi al, 2000). On top of that, it is similar to the newest HPV-DNA frequency among control women (13%) in the good concurrent instance–handle analysis inside Cali, Colombia (Munoz mais aussi al, 1996).
There is certainly zero obvious organization involving the lifetime regarding casual sexual people, age at first sexual intercourse or very first delivery, entry to IUDs or condoms and you can risk
Numerous research has ideal your prevalence from HPV disease decreases as we age, HPV being strange in cytological normal women over-age 35 ages (Melkert ainsi que al, 1993; Morrison, 1994). But not, several previous highest inhabitants-built studies away from Costa Rica and you will Mexico and shown some improve inside HPV infection certainly feamales in peri- and you can blog post-menopause ages. During Costa Rica the height try noticed in women old than 55 years, with an effective predominance from LR HPV products, within the Mexico the next top come earlier, after forty five yrs old, having predominance away from Hour HPV models along with a boost in recognition away from LR HPV models compared to the young decades.
Within our analysis the brand new HPV prevalence from the age bracket 45–54 many years try low, but you will find an elevated incidence from HPV problems in women old 55 or higher ages, having a beneficial predominance of LR products and you can several HPV problems, yet still 5.7% was in fact Hr HPV confident. If the confirmed, the possibility of HPV infection – especially LR systems – among article-menopause feminine, it could be told me in another way: (1) reactivation regarding hidden HPV attacks by diminished immune reaction. Certain immunological research has shown a decrease in dispersing adult T muscle within the the elderly down to a decrease in CD8+ lymphocytes, a decline about regularity out of CD4+ T structure producing IL-dos and/otherwise a decreased term in IL-dos receptors (Lesourd and you may Meaume, 1994; Gostout et al, 1998; Ginaldi et al, 1999). (2) Reactivation regarding hidden HPV infection from the hormonal alterations regarding the new gradual refuse out-of ovarian setting up to menopause (Lazcano ainsi que al, 2001). (3) A cohort feeling (Herrero mais aussi al, 2000), in which older feminine was confronted with the herpes virus early in existence and you may belonged so you’re able to generations a whole lot more greatly exposed to HPV infections.
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